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Human adenovirus type 2 but not adenovirus type 12 is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned rat liver epithelial cells.

Human adenovirus type 2 but not adenovirus type 12 is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned rat liver epithelial cells.

Authors :
Paraskeva C
Roberts C
Biggs P
Gallimore PH
Source :
Journal of virology [J Virol] 1983 Apr; Vol. 46 (1), pp. 131-6.
Publication Year :
1983

Abstract

Using resistance to the base analog 8-azaguanine as a genetic marker, we showed that adenovirus type 2, but not adenovirus type 12, is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned diploid rat liver epithelial cells. Adenovirus type 2 increased the frequency of 8-azaguanine-resistant colonies by up to ninefold over the spontaneous frequency, depending on expression time and virus dose.

Details

Language :
English
ISSN :
0022-538X
Volume :
46
Issue :
1
Database :
MEDLINE
Journal :
Journal of virology
Publication Type :
Academic Journal
Accession number :
6572280
Full Text :
https://doi.org/10.1128/JVI.46.1.131-136.1983