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Prooxidant properties of vanadate in vitro on catecholamines and on lipid peroxidation by mouse and rat tissues.
- Source :
-
Journal of toxicology and environmental health [J Toxicol Environ Health] 1983 Jul; Vol. 12 (1), pp. 119-26. - Publication Year :
- 1983
-
Abstract
- Vanadate (Na3VO4) in micromolar concentrations enhanced the in vitro formation of adrenochrome from epinephrine, and of aminochrome from dopamine. Lipid peroxides in various tissues of the mouse and rat, particularly brain, were increased. Products of both catecholamine oxidation and lipid peroxidation may be the basis of the cardiotoxic and neurotoxic effects of vanadium.
- Subjects :
- Adrenochrome analogs & derivatives
Adrenochrome biosynthesis
Animals
Ascorbic Acid metabolism
Dopamine analogs & derivatives
Dopamine metabolism
Drug Synergism
Epinephrine metabolism
In Vitro Techniques
Male
Malondialdehyde biosynthesis
Mice
Mice, Inbred Strains
Oxidation-Reduction drug effects
Rats
Rats, Inbred Strains
Time Factors
Vanadates
Catecholamines metabolism
Lipid Peroxides metabolism
Vanadium toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0098-4108
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of toxicology and environmental health
- Publication Type :
- Academic Journal
- Accession number :
- 6556257
- Full Text :
- https://doi.org/10.1080/15287398309530411