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Hypouricemic action of diflunisal in gouty patients: in vitro and in vivo studies.
- Source :
-
The Journal of rheumatology [J Rheumatol] 1984 Jun; Vol. 11 (3), pp. 330-2. - Publication Year :
- 1984
-
Abstract
- Sixteen hyperuricemic gouty patients were treated with diflunisal, a novel salicylate, 500 mg BID. Serum and urine uric acid along with uric acid clearances were studied before and after a 7-day treatment. A clear hypouricemic action was observed, but 2 different mechanisms of action were seen when overexcretor patients and normoexcretor patients were analyzed separately. In overexcretors an allopurinol-like action was evident, whereas in normoexcretors a uricosuric action occurred. In vitro experiments showed a competitive inhibition of xanthine-oxidase exerted by diflunisal at low concentrations.
Details
- Language :
- English
- ISSN :
- 0315-162X
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 6547486