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Prognostic significance of lymphography in stage IIIs Hodgkin's disease (HD).

Authors :
Mazza P
Miniaci G
Lauria F
Gobbi M
Emiliani E
Barbieri E
Neri S
Querzani P
Fiacchini M
Tura S
Source :
European journal of cancer & clinical oncology [Eur J Cancer Clin Oncol] 1984 Nov; Vol. 20 (11), pp. 1393-9.
Publication Year :
1984

Abstract

Ninety-six patients with pathological stage IIIs Hodgkin's disease, uniformly treated with six cycles of MOPP and TNI, were retrospectively analysed in an effort to determine whether the lymphographic aspect of lymph nodes influence the prognosis. Case material was grouped according to the presence of lymph nodes less than 3 cm in diameter or larger at lymphography. Five-year survival and disease-free survival were 85 and 78% for patients with small lymph node involvement, compared to 48 and 30% for patients with larger lymph nodes. The comparative analysis between the lymphographic aspect and other prognostic factors shows that large lymphographic involvement is strongly correlated with the presence of large spleen involvement (P less than 0.0000029), followed by stage III2 (P less than 0.000612), followed by greater than or equal to 5 involved sites (P less than 0.012), followed by age greater than 40 yr (P less than 0.047). Conversely, no significant correlation was found with symptoms, histology and mediastinal involvement. Modifications of current treatment for both large and small lymph node involvement are discussed.

Details

Language :
English
ISSN :
0277-5379
Volume :
20
Issue :
11
Database :
MEDLINE
Journal :
European journal of cancer & clinical oncology
Publication Type :
Academic Journal
Accession number :
6542008
Full Text :
https://doi.org/10.1016/0277-5379(84)90058-0