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Urinary excretion of 2,3-dinor-thromboxane B2 in man under normal conditions, following drugs and during some pathological conditions.
- Source :
-
Prostaglandins [Prostaglandins] 1984 Apr; Vol. 27 (4), pp. 627-44. - Publication Year :
- 1984
-
Abstract
- Quantitation of 2,3-dinor-thromboxane B2 (2,3-dinor-TxB2) was performed by gas chromatography-mass spectrometry. Under normal conditions the urinary excretion of 2,3-dinor-TxB2 was relatively constant in the same individual from day to day but during a 24-hour period a somewhat higher excretion rate was found during the first few hours after awakening. A pronounced reduction of the urinary excretion of 2,3-dinor-TxB2 was found after oral administration of 500 mg of aspirin or 50 mg of indomethacin, while 500 mg of paracetamol did not affect the urinary excretion. Increased excretion of 2,3-dinor-TxB2 was found in normal pregnancies and in diseases such as diabetes mellitus and homocysteinuria in comparison to the urinary excretion in normal healthy subjects. We also report one case, where the urinary excretion of 2,3-dinor-TxB2 was increased for a short period following the first symptoms of a myocardial infarction and those data indicate that thromboxane A2 (TxA2) may be of pathophysiological importance in human myocardial infarction. The results strongly indicate that measurements of the urinary excretion of 2,3-dinor-TxB2 should be meaningful as a tool for investigation of the involvement of thromboxane in various pathophysiological processes in vivo in man.
- Subjects :
- Acetaminophen pharmacology
Adult
Amino Acid Metabolism, Inborn Errors urine
Aspirin pharmacology
Circadian Rhythm
Diabetes Mellitus urine
Female
Humans
Indomethacin pharmacology
Male
Myocardial Infarction urine
Physical Exertion
Pregnancy
Reference Values
Thromboxane B2 analogs & derivatives
Thromboxane B2 urine
Thromboxanes urine
Subjects
Details
- Language :
- English
- ISSN :
- 0090-6980
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Prostaglandins
- Publication Type :
- Academic Journal
- Accession number :
- 6539491
- Full Text :
- https://doi.org/10.1016/0090-6980(84)90098-4