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Plasma testosterone transport in primates.
- Source :
-
Journal of steroid biochemistry [J Steroid Biochem] 1984 Jan; Vol. 20 (1), pp. 473-8. - Publication Year :
- 1984
-
Abstract
- All primate species, including Old and New World primates and prosimians have a plasma testosterone-estradiol binding globulin (TeBG), which is a glycoprotein and has a similar mobility in polyacrylamide gel electrophoresis. In New World primates the TeBG binding capacity for [3H]testosterone was higher and its affinity lower than in Old World primates. These changes were associated with high unbound plasma testosterone concentrations in these species. Binding parameters of TeBG in prosimian species varied markedly. Thus, in primate evolution TeBG was conserved despite marked differences in binding characteristics. In New World primates changes are associated with high total and unbound testosterone, a finding concordant with alterations of other steroid hormones concentration in these species with "generalized steroid hormone resistance".
Details
- Language :
- English
- ISSN :
- 0022-4731
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of steroid biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 6538618
- Full Text :
- https://doi.org/10.1016/0022-4731(84)90256-5