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Tetracyclines inhibit parathyroid hormone-induced bone resorption in organ culture.
- Source :
-
Experientia [Experientia] 1984 Nov 15; Vol. 40 (11), pp. 1273-5. - Publication Year :
- 1984
-
Abstract
- Several tetracyclines (minocycline, doxycycline, tetracycline), in levels approximating physiologic concentrations, were found to inhibit parathyroid hormone-induced bone resorption in organ culture; the specificity of this effect was demonstrated by comparison with other (non-tetracycline) types of antibiotics. The ability of tetracyclines to inhibit bone resorption is consistent with the recent proposal by Golub et al. that these antibiotics can inhibit mammalian collagenolytic enzymes by a mechanism unrelated to the drug's antibacterial efficacy, a property which could be therapeutically useful in diseases characterized by excessive collagen breakdown.
- Subjects :
- Animals
Bone and Bones embryology
Calcium metabolism
Collagen metabolism
Doxycycline pharmacology
Female
Minocycline pharmacology
Organ Culture Techniques
Pregnancy
Rats
Rats, Inbred Strains
Tetracycline pharmacology
Bone Resorption drug effects
Bone and Bones physiology
Parathyroid Hormone antagonists & inhibitors
Tetracyclines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-4754
- Volume :
- 40
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Experientia
- Publication Type :
- Academic Journal
- Accession number :
- 6500016
- Full Text :
- https://doi.org/10.1007/BF01946671