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A pharmacologically pertinent animal model of mania.
- Source :
-
Journal of affective disorders [J Affect Disord] 1981 Dec; Vol. 3 (4), pp. 381-7. - Publication Year :
- 1981
-
Abstract
- Intraventricular injection of 6-hydroxydopamine (HDA) produces rats which are irritable and hyperresponsive to environmental stimuli. Chronic administration of lithium was found to prevent the development of hyperreactivity to mild footshock, while chronic electroconvulsive shock effected a return toward normal behavior. HDA-induced hyperreactivity is proposed as a pharmacological model of mania.
- Subjects :
- Animals
Disease Models, Animal
Electroshock
Humans
Imipramine pharmacology
Injections, Intraventricular
Lactates pharmacology
Lactic Acid
Lithium pharmacology
Male
Motor Activity drug effects
Oxidopamine
Rats
Rats, Inbred Strains
Affective Disorders, Psychotic chemically induced
Bipolar Disorder chemically induced
Hydroxydopamines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-0327
- Volume :
- 3
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 6459353
- Full Text :
- https://doi.org/10.1016/0165-0327(81)90006-9