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Heparin - an examination of its antibacterial adsorption properties.
- Source :
-
European urology [Eur Urol] 1981; Vol. 7 (6), pp. 359-62. - Publication Year :
- 1981
-
Abstract
- One of the primary antibacterial defense mechanisms of the bladder is the action of the luminal mucopolysaccharide layer against adsorption of inoculated bacteria. Previous studies have shown that local instillation of the mucopolysaccharide heparin can prevent bacterial adsorption on the bladder mucosa denuded of this "antiadherence factor". To determine whether this action was due to the mucopolysaccharide composition of heparin, or rather to its anticoagulant property, protamine sulfate (a basic protein with anticoagulant properties) was tested for antiadsorptive efficacy. Protamine offered no protection against bacterial adherence in the rabbit model. It appears that heparin's protective effect is unrelated to its action as an anticoagulant.
- Subjects :
- Animals
Cell Adhesion drug effects
Escherichia coli drug effects
Glycosaminoglycans physiology
Heparin administration & dosage
Male
Mucous Membrane physiology
Rabbits
Urinary Bladder physiology
Escherichia coli Infections prevention & control
Heparin pharmacology
Mucous Membrane drug effects
Urinary Bladder drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0302-2838
- Volume :
- 7
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European urology
- Publication Type :
- Academic Journal
- Accession number :
- 6456911
- Full Text :
- https://doi.org/10.1159/000473265