[Chromosome aberrations in F1 (NZBxNZW) mice--an experimental model of systemic lupus erythematosus].

Authors :: Skazkina OIa
Lil'p IG
Pleskovskaia GN
Tugolukova SS
Korogodina IuV
Source :: TSitologiia i genetika [Tsitol Genet] 1984 Nov-Dec; Vol. 18 (6), pp. 458-9.
Publication Year :: 1984
Abstract: Spontaneous and mitomycin-C-induced chromosomal aberration level was studied in bone marrow cells of mice F1 (NZBXNZW), an experimental model of systemic lupus erythematosus and in C57BL/6J mice. The chromosome instability level is found to correspond to the degree of the autoimmune process: F1 (NZBXNZW) mice with the highest titer of autoantibodies to DNA has higher chromosomal mutability.

Subjects :: Animals
Autoimmune Diseases genetics
Bone Marrow drug effects
Bone Marrow ultrastructure
Female
Male
Mice
Mitomycin
Mitomycins pharmacology
Chromosome Aberrations
Disease Models, Animal
Lupus Erythematosus, Systemic genetics
Mice, Inbred NZB genetics

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