Experimental induction of oral squamous cell carcinomas in mice with 4-nitroquinolone-1-oxide.

Authors :: Steidler NE
Reade PC
Source :: Oral surgery, oral medicine, and oral pathology [Oral Surg Oral Med Oral Pathol] 1984 May; Vol. 57 (5), pp. 524-31.
Publication Year :: 1984
Abstract: The oral mucosa of mice is resistant to the action of a variety of carcinogens. In this study, the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was applied repeatedly to the palates of male CBA mice for 2, 4, 6, 8, 12, or 16 weeks, and the animals were observed for the remainder of the 50-week experimental period. Oral epithelial atypia and squamous cell carcinoma were observed with increasing prevalence as the period of carcinogen exposure was increased. Carcinomas developed by 50 weeks in all animals that received 4NQO for 16 weeks.

Subjects :: Animals
Carcinoma, Squamous Cell pathology
Male
Mice
Mice, Inbred CBA
Mouth Mucosa drug effects
Mouth Mucosa pathology
Mouth Neoplasms pathology
Neoplasms, Experimental chemically induced
Palatal Neoplasms chemically induced
Palatal Neoplasms pathology
Time Factors
Tongue Neoplasms chemically induced
Tongue Neoplasms pathology
4-Nitroquinoline-1-oxide adverse effects
Carcinoma, Squamous Cell chemically induced
Mouth Neoplasms chemically induced
Nitroquinolines adverse effects

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