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Meningococcal group B vaccine trial in Norway 1981--1982. Preliminary report of results available November 1982.
- Source :
-
NIPH annals [NIPH Ann] 1983 Dec; Vol. 6 (2), pp. 133-8. - Publication Year :
- 1983
-
Abstract
- A combined serogroup B capsular polysaccharide and serotype 2a outer membrane complex meningococcal vaccine and a placebo preparation were tested double-blindly in 55 adult, male volunteers. The vaccine gave twofold increased binding antibodies, measured by ELISA, against non-capsular outer membrane antigen in 85 per cent of those vaccinated. Bactericidal antibodies towards a meningococcal serogroup C serotype 2a strain also increased fourfold or more among 85% vaccinated. New acquisition of meningococcal carriage was associated with antibody increase in one person from the placebo group.
- Subjects :
- Antibodies, Bacterial analysis
Antibody Formation
Bacterial Outer Membrane Proteins
Bacterial Proteins immunology
Clinical Trials as Topic
Double-Blind Method
Enzyme-Linked Immunosorbent Assay
Humans
Male
Membrane Proteins immunology
Norway
Bacterial Vaccines administration & dosage
Meningococcal Infections prevention & control
Neisseria meningitidis immunology
Vaccination
Subjects
Details
- Language :
- English
- ISSN :
- 0332-5652
- Volume :
- 6
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- NIPH annals
- Publication Type :
- Academic Journal
- Accession number :
- 6427703