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Meningococcal group B vaccine trial in Norway 1981--1982. Preliminary report of results available November 1982.

Authors :
Frøholm LO
Berdal BP
Bøvre K
Gaustad P
Harboe A
Holten E
Høiby EA
Lystad A
Omland T
Frasch CE
Source :
NIPH annals [NIPH Ann] 1983 Dec; Vol. 6 (2), pp. 133-8.
Publication Year :
1983

Abstract

A combined serogroup B capsular polysaccharide and serotype 2a outer membrane complex meningococcal vaccine and a placebo preparation were tested double-blindly in 55 adult, male volunteers. The vaccine gave twofold increased binding antibodies, measured by ELISA, against non-capsular outer membrane antigen in 85 per cent of those vaccinated. Bactericidal antibodies towards a meningococcal serogroup C serotype 2a strain also increased fourfold or more among 85% vaccinated. New acquisition of meningococcal carriage was associated with antibody increase in one person from the placebo group.

Details

Language :
English
ISSN :
0332-5652
Volume :
6
Issue :
2
Database :
MEDLINE
Journal :
NIPH annals
Publication Type :
Academic Journal
Accession number :
6427703