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Polysaccharides in fungi. XIV. Anti-inflammatory effect of the polysaccharides from the fruit bodies of several fungi.
- Source :
-
Journal of pharmacobio-dynamics [J Pharmacobiodyn] 1983 Dec; Vol. 6 (12), pp. 983-90. - Publication Year :
- 1983
-
Abstract
- Anti-inflammatory assays on the carrageenin-induced edema and scald-induced hyperalgesia in the hindpaw of rats were studied on polysaccharides obtained from the fruit bodies of various fungi (polysaccharide AC, BC: Tremella fuciformis;MEA, MHA, MCW-A, MCW-N: Auricularia auricula-judae; T-2-HN: Dictophora indusiata;G-A: Ganoderma japonicum). The purified polysaccharides MHA, MCW-A, G-A and T-2-HN exhibited a significant inhibitory effect on carrageenin edema. Among these polysaccharides, T-2-HN (partially O-acetylated alpha-D-mannan) also showed the marked inhibitory effect on scald hyperalgesia. We have found that T-2-HN has more potent anti-inflammatory activity than phenylbutazone in the above two inflammatory models. Since the purified polysaccharide is free from protein and lipid, it is clear that anti-inflammatory effect arises from the polysaccharide itself. The polysaccharides (T-2-HN, locust bean gun, xanthan gum) had little effect on the metabolism of arachidonic acid in canine platelets. The mechanism of the anti-inflammatory activity of the polysaccharide remains obscure.
- Subjects :
- Animals
Arachidonic Acid
Arachidonic Acids blood
Blood Platelets drug effects
Blood Platelets metabolism
Carrageenan
Dogs
Edema chemically induced
Edema physiopathology
Pain drug therapy
Polysaccharides isolation & purification
Rats
Rats, Inbred Strains
Anti-Inflammatory Agents
Basidiomycota analysis
Polysaccharides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0386-846X
- Volume :
- 6
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of pharmacobio-dynamics
- Publication Type :
- Academic Journal
- Accession number :
- 6425490
- Full Text :
- https://doi.org/10.1248/bpb1978.6.983