Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model.

Authors :: Sunalp M
Wiedemann P
Sorgente N
Ryan SJ
Source :: Current eye research [Curr Eye Res] 1984 Apr; Vol. 3 (4), pp. 619-23.
Publication Year :: 1984
Abstract: The effects of adriamycin, 5-fluorouracil, methotrexate, triamcinolone and Viroptic on an experimental model of proliferative vitreoretinopathy (PVR) produced by the injection of homologous dermal fibroblasts into the rabbit vitreous were studied. Adriamycin and fluorouracil inhibited fibroblast proliferation and prevented the formation of membranes as well as did triamcinolone, whereas methotrexate and Viroptic had no beneficial effect in this model of PVR.

Subjects :: Animals
Antineoplastic Agents pharmacology
Disease Models, Animal
Doxorubicin therapeutic use
Eye Diseases drug therapy
Female
Fibroblasts drug effects
Fluorouracil therapeutic use
Male
Methotrexate therapeutic use
Rabbits
Triamcinolone therapeutic use
Trifluridine therapeutic use
Antineoplastic Agents therapeutic use
Retinal Detachment drug therapy
Retinal Diseases drug therapy
Vitreous Body drug effects

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