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New concepts about the pathogenesis of atherosclerosis in diabetes mellitus.
- Source :
-
The American journal of medicine [Am J Med] 1983 Nov 30; Vol. 75 (5B), pp. 67-80. - Publication Year :
- 1983
-
Abstract
- New concepts about the pathogenesis of atherosclerosis in diabetes mellitus are presented. Emphasis is given to alterations of endothelial function, as indicated by von Willebrand factor activity, prostacyclin release, and fibrinolytic activity in diabetes mellitus. Previous work on platelet aggregation and arachidonic acid metabolism is updated and recent findings are emphasized. The atherogenic mix of elevated low-density lipoprotein cholesterol and low high-density lipoprotein cholesterol levels in uncontrolled diabetes mellitus is noted. The lipid hypothesis is extended by consideration of very low-density lipoprotein and intermediate-density lipoprotein metabolism in diabetes. Lipoprotein-cell interactions that may contribute to atherosclerosis are reviewed and suggestions are made for future research in order to clarify the pathogenesis of atherosclerosis in diabetes mellitus.
- Subjects :
- Animals
Arachidonic Acid
Arachidonic Acids metabolism
Blood Platelets metabolism
Cholesterol metabolism
Cholesterol, HDL
Cholesterol, LDL
Diabetes Mellitus metabolism
Endothelium metabolism
Epoprostenol metabolism
Fibrinolysis
Humans
Lipoproteins metabolism
Lipoproteins, HDL metabolism
Lipoproteins, IDL
Lipoproteins, LDL metabolism
Lipoproteins, VLDL metabolism
Plasminogen Activators metabolism
Platelet Aggregation
von Willebrand Factor analysis
Arteriosclerosis etiology
Diabetic Angiopathies etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9343
- Volume :
- 75
- Issue :
- 5B
- Database :
- MEDLINE
- Journal :
- The American journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 6424441
- Full Text :
- https://doi.org/10.1016/0002-9343(83)90256-5