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A double-blind study of bupropion and placebo in depression.
- Source :
-
The American journal of psychiatry [Am J Psychiatry] 1984 Apr; Vol. 141 (4), pp. 525-9. - Publication Year :
- 1984
-
Abstract
- Bupropion HCl, a new nontricyclic antidepressant, produced marked improvement in 49 hospitalized patients with primary depression at doses of 300-600 mg/day. Bupropion resulted in statistically significant differences from placebo as early as day 5, and by the end of the 4-week study 79% (N = 27) of the bupropion patients and 13% (N = 2) of the placebo patients showed much to very much improvement. Bupropion and placebo had similar side effect profiles. Tremor and sweating were reported more often with bupropion and headache, nausea, and tiredness with placebo.
- Subjects :
- Adult
Aged
Antidepressive Agents adverse effects
Body Weight
Bupropion
Clinical Trials as Topic
Depressive Disorder psychology
Double-Blind Method
Female
Hospitalization
Humans
Male
Middle Aged
Personality Inventory
Placebos
Propiophenones adverse effects
Psychiatric Status Rating Scales
Sweating
Tremor chemically induced
Antidepressive Agents therapeutic use
Depressive Disorder drug therapy
Propiophenones therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0002-953X
- Volume :
- 141
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The American journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 6422779
- Full Text :
- https://doi.org/10.1176/ajp.141.4.525