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[Calcium dependent hepatotoxicity of the ionophore A23187 studied by the experimental model of rat liver isolated and perfused in vitro].
[Calcium dependent hepatotoxicity of the ionophore A23187 studied by the experimental model of rat liver isolated and perfused in vitro].
- Source :
-
Bollettino della Societa italiana di biologia sperimentale [Boll Soc Ital Biol Sper] 1983 Nov 30; Vol. 59 (11), pp. 1711-3. - Publication Year :
- 1983
-
Abstract
- Ionophore A23187, an agent that promoves Ca2+ influx into cells, significantly increases enzymatic leakage of AST and LDH into the medium by perfused rat livers. This work provides evidence that Ca2+ dependent hepatotoxicity can be studied conveniently in vitro whit isolated and perfused rat livers, since this model respects integrity of organ and duplicates many its in vivo functions.
Details
- Language :
- Italian
- ISSN :
- 0037-8771
- Volume :
- 59
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Bollettino della Societa italiana di biologia sperimentale
- Publication Type :
- Academic Journal
- Accession number :
- 6421297