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[Calcium dependent hepatotoxicity of the ionophore A23187 studied by the experimental model of rat liver isolated and perfused in vitro].

[Calcium dependent hepatotoxicity of the ionophore A23187 studied by the experimental model of rat liver isolated and perfused in vitro].

Authors :
Andreana A
Perna P
DiLillo MA
Source :
Bollettino della Societa italiana di biologia sperimentale [Boll Soc Ital Biol Sper] 1983 Nov 30; Vol. 59 (11), pp. 1711-3.
Publication Year :
1983

Abstract

Ionophore A23187, an agent that promoves Ca2+ influx into cells, significantly increases enzymatic leakage of AST and LDH into the medium by perfused rat livers. This work provides evidence that Ca2+ dependent hepatotoxicity can be studied conveniently in vitro whit isolated and perfused rat livers, since this model respects integrity of organ and duplicates many its in vivo functions.

Details

Language :
Italian
ISSN :
0037-8771
Volume :
59
Issue :
11
Database :
MEDLINE
Journal :
Bollettino della Societa italiana di biologia sperimentale
Publication Type :
Academic Journal
Accession number :
6421297