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Blood and serum concentrations of gold after a single dose of auranofin in children with juvenile rheumatoid arthritis.
- Source :
-
The Journal of rheumatology [J Rheumatol] 1983 Jun; Vol. 10 (3), pp. 496-8. - Publication Year :
- 1983
-
Abstract
- Three children with juvenile rheumatoid arthritis were given a single oral dose of approximately 0.1 mg/kg of auranofin. Blood concentrations up to 49 ng/ml were detectable at 24 h (earliest sample) and remained detectable for at least 2 weeks (final sample). Disappearance of measurable gold from both the blood and serum appeared to be linear through time. None of the patients experienced significant laboratory abnormalities nor adverse reactions. Gold levels attained in these children were somewhat lower than those seen in adults administered an equivalent dose.
- Subjects :
- Administration, Oral
Anti-Inflammatory Agents administration & dosage
Auranofin
Aurothioglucose administration & dosage
Aurothioglucose blood
Child
Female
Half-Life
Humans
Male
Anti-Inflammatory Agents blood
Arthritis, Juvenile drug therapy
Aurothioglucose analogs & derivatives
Gold analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0315-162X
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 6411921