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Study on the anti-hypoxic effect of cinnarizine and its interaction with prostacyclin.
- Source :
-
Methods and findings in experimental and clinical pharmacology [Methods Find Exp Clin Pharmacol] 1984 Mar; Vol. 6 (3), pp. 135-8. - Publication Year :
- 1984
-
Abstract
- The anti-hypoxic effect of cinnarizine was studied using the following experimental methods: hypobaric and anoxic hypoxia in mice, complete ischemia by decapitation in mice and hemic hypoxia in rats. Papaverine, xanthinol nicotinate and naftidrofuryl were used as reference drugs. In hypobaric and anoxic hypoxia the interaction of cinnarizine with the effect of prostacyclin (PGI2) was investigated. Cinnarizine showed an anti-hypoxic effect in all the methods used. It was more effective in hypobaric and anoxic hypoxia, in incomplete ischemia by decapitation, and less effective in hemic hypoxia. Cinnarizine potentiated the effect of PGI2 shifting the anti-hypoxic dose-response curve of PGI2 to the left. Suggestions as to the possible mechanism of anti-hypoxic action of cinnarizine are made.
- Subjects :
- Animals
Atmospheric Pressure
Brain blood supply
Drug Interactions
Hypoxia physiopathology
Ischemia physiopathology
Male
Mice
Nafronyl pharmacology
Oxygen blood
Papaverine pharmacology
Rats
Rats, Inbred Strains
Xanthinol Niacinate pharmacology
Cinnarizine therapeutic use
Epoprostenol therapeutic use
Hypoxia drug therapy
Piperazines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0379-0355
- Volume :
- 6
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Methods and findings in experimental and clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 6379343