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Absorption of soluble and isophane semi-synthetic human and porcine insulin in insulin-dependent diabetic subjects.
- Source :
-
Acta endocrinologica [Acta Endocrinol (Copenh)] 1984 Feb; Vol. 105 (2), pp. 215-20. - Publication Year :
- 1984
-
Abstract
- A double-blind cross-over study of the sc absorption of radiolabelled semi-synthetic human (SHI) and purified porcine (PPI) insulin was made. Absorption of both isophane (n = 10) and soluble insulin (n = 8) was studied. There was no significant difference between the disappearance from the injection site, the plasma free insulin concentrations, or blood glucose levels after sc injection of the isophane preparations. A faster disappearance of the soluble SHI (as judged from T/50 and AUC) was found (both P-values less than 0.01). However, no difference was observed between the plasma insulin concentrations at any time point (P less than 0.05). Blood glucose levels showed no statistical differences between the two soluble preparations. The data indicate minor differences between the pharmacokinetics of SHI and PPI, but these seem of no clinical importance.
- Subjects :
- Absorption
Adult
Animals
Blood Glucose analysis
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Injections, Subcutaneous
Insulin chemical synthesis
Insulin therapeutic use
Insulin, Isophane chemical synthesis
Insulin, Isophane therapeutic use
Male
Middle Aged
Receptor, Insulin metabolism
Swine
Diabetes Mellitus, Type 1 drug therapy
Insulin metabolism
Insulin, Isophane metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0001-5598
- Volume :
- 105
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta endocrinologica
- Publication Type :
- Academic Journal
- Accession number :
- 6364670
- Full Text :
- https://doi.org/10.1530/acta.0.1050215