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[A controlled clinical single-dose comparative study of suprofen and diflunisal].
- Source :
-
Arzneimittel-Forschung [Arzneimittelforschung] 1983; Vol. 33 (9), pp. 1331-4. - Publication Year :
- 1983
-
Abstract
- In a single-dose, double-blind randomized study, the analgesic efficacy of suprofen 200, suprofen (alpha-methyl-4-(2-thienylcarbonyl)-benzene acetic acid; Suprol) 400 mg and diflunisal 750 mg capsules was determined in comparison to placebo capsules. A total of 130 patients participated in the study, all of them requiring analgesic treatment on the first post-operative day following meniscectomy. The treatment groups were homogeneous with respect to their demographic data. With the chosen pain model all active test substances were statistically significantly superior to placebo as far as pain intensity differences (SPID), pain relief (TOTPAR) and global evaluation of efficacy were concerned. Despite great differences in dosage and half-life, the active test substances must be regarded as equipment. Side effects were reported by 2 patients each in the diflunisal 750 mg and the placebo group, and by 1 patient treated with suprofen 200 mg.
- Subjects :
- Adolescent
Adult
Clinical Trials as Topic
Diflunisal adverse effects
Double-Blind Method
Female
Humans
Male
Middle Aged
Suprofen adverse effects
Time Factors
Diflunisal therapeutic use
Pain, Postoperative drug therapy
Phenylpropionates therapeutic use
Salicylates therapeutic use
Suprofen therapeutic use
Subjects
Details
- Language :
- German
- ISSN :
- 0004-4172
- Volume :
- 33
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Arzneimittel-Forschung
- Publication Type :
- Academic Journal
- Accession number :
- 6357208