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Survey of plant inhibitors of polymorphonuclear leukocyte elastase, pancreatic elastase, cathepsin G, cathepsin B, Hageman factor fragments, and other serine proteinases.
- Source :
-
Biochemical pharmacology [Biochem Pharmacol] 1983 Mar 15; Vol. 32 (6), pp. 985-90. - Publication Year :
- 1983
-
Abstract
- Various flower bulbs and vegetable and legume seeds were tested for inhibitors of polymorphonuclear leukocyte elastase, pancreatic elastase, cathepsin G, cathepsin B, trypsin, alpha-chymotrypsin, Hageman factor fragments, plasma kallikrein, and plasmin. Calla bulbs contained a 33,000 dalton polymorphonuclear leukocyte elastase inhibitor and a 4,000 dalton cathepsin G inhibitor. Seeds of some members in the Cruciferae family, such as radish and broccoli, were found to contain one or more 2,500-4,000 dalton inhibitors which inhibited cathepsin G, trypsin, Hageman factor fragments, and plasmin, but not plasma kallikrein. These seeds also contained a 1,000 dalton cathepsin B inhibitor. The above inhibitors were probably polypeptides which inhibited proteinases by making an enzyme-inhibitor complex, with the exception of the cathepsin B inhibitor. These newly found inhibitors with their characteristic profiles of inhibition should be useful in biochemical and pathophysiological studies on granulocyte proteinases and enzymes of the coagulation and fibrinolytic pathways.
- Subjects :
- Cathepsin B
Cathepsin G
Cathepsins antagonists & inhibitors
Factor XII antagonists & inhibitors
Factor XIIa
Humans
In Vitro Techniques
Pancreatic Elastase antagonists & inhibitors
Peptide Fragments antagonists & inhibitors
Serine Endopeptidases
Species Specificity
Neutrophils enzymology
Pancreas enzymology
Plant Extracts pharmacology
Protease Inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0006-2952
- Volume :
- 32
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biochemical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 6340694
- Full Text :
- https://doi.org/10.1016/0006-2952(83)90615-9