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Trimethoprim-sulfamethoxazole therapy for Nocardia infections.
- Source :
-
Archives of internal medicine [Arch Intern Med] 1983 Apr; Vol. 143 (4), pp. 711-8. - Publication Year :
- 1983
-
Abstract
- The optimal therapy for infections due to Nocardia species has not been established. To assess the efficacy of trimethoprim-sulfamethoxazole (TMP-SMX), we reviewed the records of 19 patients with Nocardia infections seen at Duke University Medical Center, Durham, NC, who were treated with this drug, either alone or in combination with other antibiotics or a surgical procedure. Underlying diseases or therapy causing immunosuppression were present in all but five cases. Sites of involvement were lung (ten of 19), wound (two of 19), and brain (two of 19); five of 19 patients had disseminated disease. The mean duration of therapy was 7.2 months. Overall cure or improvement was achieved in 89% (17/19) of cases; 80% of patients with disseminated disease and 60% of those with CNS involvement recovered. This experience, and accumulated clinical evidence in the literature, indicates that TMP-SMX should be considered the therapeutic drug of choice in infections due to Nocardia species.
- Subjects :
- Administration, Oral
Adolescent
Adult
Aged
Anti-Bacterial Agents administration & dosage
Brain microbiology
Central Nervous System microbiology
Child
Drug Evaluation
Drug Synergism
Female
Humans
Immunosuppression Therapy
Lung microbiology
Male
Middle Aged
Nocardia Infections surgery
Nocardia asteroides isolation & purification
Retrospective Studies
Sulfamethoxazole blood
Sulfamethoxazole cerebrospinal fluid
Time Factors
Trimethoprim blood
Trimethoprim cerebrospinal fluid
Wounds and Injuries microbiology
Nocardia Infections drug therapy
Sulfamethoxazole administration & dosage
Trimethoprim administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9926
- Volume :
- 143
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archives of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 6340623