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[Artificial blood. Experimental studies on fluorocarbons as chemical blood substitutes].
- Source :
-
Minerva medica [Minerva Med] 1983 Jan 14; Vol. 74 (1-2), pp. 1-18. - Publication Year :
- 1983
-
Abstract
- Fluorocarbonates are organic compounds capable of carrying oxygen and surrendering it to tissues by means of biological sound modalities. Experimentation of an emulsion consisting of perfluorotripropylamine and perfluorodecaline (Fluosol DA 20%) as a blood substitute is reported. Acute (Ht less than 1%) and chronic morphological (Ht = 15%) studies were performed on rats, and a semi-acute biochemical and morphological protocol (Ht = 21%) was experimented in pigs. The first signs of altered cerebral electrical activity occurred at Ht = 2% in the acute experiments, and death due to respiratory arrest took pace at Ht = 0.5%. In the semiacute and chronic experiments, widespread infiltration of fluorocarbonic micelles was noted on histological and electron microscope lung and liver preparations.
- Subjects :
- Acid-Base Equilibrium drug effects
Animals
Biological Transport
Blood Glucose analysis
Blood Pressure drug effects
Carbon Monoxide Poisoning therapy
Central Venous Pressure drug effects
Diuresis drug effects
Drug Combinations pharmacology
Electrocardiography
Electroencephalography
Electromyography
Emulsions
Fluorocarbons metabolism
Gelatin pharmacology
Heart Rate drug effects
Hematocrit
Hemodilution
Hemorrhage therapy
Hydroxyethyl Starch Derivatives
Liver drug effects
Mononuclear Phagocyte System drug effects
Oxygen Consumption
Prothrombin Time
Rats
Tissue Preservation
Transplantation
Blood Substitutes
Fluorocarbons pharmacology
Subjects
Details
- Language :
- Italian
- ISSN :
- 0026-4806
- Volume :
- 74
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Minerva medica
- Publication Type :
- Academic Journal
- Accession number :
- 6337348