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Oncogenes: implications for the diagnosis and treatment of cancer.
- Source :
-
Annals of internal medicine [Ann Intern Med] 1984 Aug; Vol. 101 (2), pp. 223-33. - Publication Year :
- 1984
-
Abstract
- Cellular oncogenes comprise a small family of genes, highly conserved throughout vertebrate evolution, that code for proteins with diverse functions including DNA binding, protein kinase, and cellular growth factor activities. Cellular oncogenes are important in certain aspects of the proliferation and differentiation of normal cells. Under some circumstances these genes may also induce malignant transformation of normal cells. Various mechanisms may underlie their involvement in carcinogenesis. Incorporation of all, or part of, cellular oncogenes into RNA tumor viruses, mutations in gene structure, or translocation of cellular oncogenes from one chromosome to another may all be associated with the induction of malignant change in cells. In some of these situations altered oncogene products are made. Knowledge about the biology of oncogenes may lead to improved techniques for cancer detection and perhaps new approaches to cancer treatment.
- Subjects :
- Animals
Avian Myeloblastosis Virus genetics
Base Sequence
Cell Differentiation
Cell Division
Cell Line
Cell Transformation, Neoplastic
DNA, Viral physiology
DNA-Binding Proteins metabolism
Growth Substances physiology
Humans
Neoplasm Proteins genetics
Neoplasms diagnosis
Neoplasms therapy
Phosphotransferases metabolism
Protein Biosynthesis
Retroviridae genetics
Retroviridae growth & development
Transformation, Genetic
Translocation, Genetic
Viral Proteins genetics
Viral Proteins physiology
Neoplasms genetics
Oncogenes
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4819
- Volume :
- 101
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annals of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 6331242
- Full Text :
- https://doi.org/10.7326/0003-4819-101-2-223