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Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS.
- Source :
-
Science (New York, N.Y.) [Science] 1984 Jul 20; Vol. 225 (4659), pp. 321-3. - Publication Year :
- 1984
-
Abstract
- Lymphadenopathy-associated virus ( LAV ), a human T- lymphotrophic retrovirus isolated from a homosexual man with lymphadenopathy, has been causally associated with acquired immunodeficiency syndrome (AIDS). A sensitive and specific radioimmunoprecipitation test was developed for the detection of antibodies to the major core protein of LAV , p25 (molecular weight 25,000). Antibody to LAV p25 was found in the serum of 51 of 125 AIDS patients, 81 of 113 patients with lymphadenopathy syndrome, 0 of 70 workers at the Centers for Disease Control (some of whom had handled specimens from AIDS patients), and 0 of 189 random blood donors. Of a group of 100 homosexual men from San Francisco whose serum was obtained in 1978, only one had antibody to LAV p25; in contrast, of a group of 50 homosexual men in the same community whose serum was obtained in 1984, 12 had antibodies to LAV p25.
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 225
- Issue :
- 4659
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 6330889
- Full Text :
- https://doi.org/10.1126/science.6330889