Back to Search
Start Over
Pneumocystis carinii pneumonia in renal-transplant recipients treated with cyclosporine and steroids.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1984 Feb; Vol. 149 (2), pp. 143-7. - Publication Year :
- 1984
-
Abstract
- Fourteen of 156 renal-transplant recipients treated with cyclosporine and steroids developed Pneumocystis carinii-related pneumonia (PCP) over a 19-month period. This was a significant change from past experience with this disease in renal-transplant patients receiving azathioprine and steroids (six cases among 179 patients from 1977 to 1981). Epidemiological investigation failed to implicate either person-to-person or nosocomial spread of infection. Cases of PCP occurred more frequently in males. Twelve patients (86%) had onset of disease in the third or fourth months after transplantation. Comparison of cases to matched controls revealed that the cases had received lower doses of steroids and had a higher incidence of cytomegalovirus infection. This suggested that the cases may have been more effectively immunosuppressed than the controls. After institution of prophylaxis with trimethoprim-sulfamethoxazole, no further cases of PCP developed.
- Subjects :
- Adolescent
Adult
Aged
Cyclosporins administration & dosage
Cytomegalovirus Infections immunology
Drug Combinations therapeutic use
Female
Humans
Male
Middle Aged
Pneumonia, Pneumocystis drug therapy
Pneumonia, Pneumocystis transmission
Risk
Sex Factors
Steroids administration & dosage
Sulfamethoxazole therapeutic use
Trimethoprim therapeutic use
Trimethoprim, Sulfamethoxazole Drug Combination
Cyclosporins therapeutic use
Kidney Transplantation
Pneumonia, Pneumocystis immunology
Steroids therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 149
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 6321606
- Full Text :
- https://doi.org/10.1093/infdis/149.2.143