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Immunological studies of beta-adrenergic receptors.
- Source :
-
Journal of cellular biochemistry [J Cell Biochem] 1983; Vol. 21 (3), pp. 187-93. - Publication Year :
- 1983
-
Abstract
- Two types for antibodies have been raised against the beta-adrenergic receptor: either by injection of highly purified receptor from turkey erythrocytes or by injection of anticatecholamine ligand antibodies, and induction of anti-idiotypic antibodies. Our data illustrate the interactions of the beta-adrenergic receptor with these polyclonal antibodies. Preliminary results with monoclonal antibodies are also described. The redistribution of beta-receptors on intact cells is visualized by the use of fluorescent antibodies. Immunoprecipitation of radioiodinated receptor by the antireceptor antibodies yields a single major 60,000 MW component.
- Subjects :
- Adenylyl Cyclases metabolism
Animals
Antibodies isolation & purification
Antibodies, Monoclonal isolation & purification
Antibody Formation
Chromatography, Affinity
Enzyme-Linked Immunosorbent Assay
Erythrocytes metabolism
Fluorescent Antibody Technique
Turkeys
Receptors, Adrenergic, beta immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0730-2312
- Volume :
- 21
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of cellular biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 6313707
- Full Text :
- https://doi.org/10.1002/jcb.240210301