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[Effect of zinc deficiency on 3',5'-cyclic-AMP content and parameters of energy metabolism in the rat].
- Source :
-
Zeitschrift fur Ernahrungswissenschaft [Z Ernahrungswiss] 1983 Jun; Vol. 22 (2), pp. 116-23. - Publication Year :
- 1983
-
Abstract
- Loss of appetite, strongly reduced feed intake, and stop in weight gain are characteristic signs of alimentary zinc deficiency. The present paper investigates some parameters of the energy metabolism of Zn-deficient rats in order to obtain information on possible disturbances. The blood of Zn-deficient rats showed an increased activity of adenosine triphosphatase (ATPase) in comparison to ad-libitum- and pair-fed control animals. Therefore the concentration of adenosine triphosphate (ATP) was reduced and the concentration of adenosine diphosphate (ADP) increased in deficient animals. As a consequence, the ratio ATP/ADP was strongly reduced in Zn-deficient rats compared with both control groups. The concentration of adenosine monophosphate (AMP) was reduced in the blood of Zn-deficient rats. The levels of c-AMP in serum and urine were markedly increased in Zn-deficient rats in comparison with both control groups. Key enzymes of energetic utilization of carbohydrates such as fructose-1.6-biphosphatase and glucose-6-phosphate dehydrogenase were reduced in their activities in livers and kidneys of Zn-deficient animals. The results show that alimentary Zn deficiency impairs some parameters of the energy metabolism. The problems of reduced feed intake in Zn deficiency still remain unsolved.
- Subjects :
- Adenosine Diphosphate blood
Adenosine Monophosphate blood
Adenosine Triphosphatases blood
Adenosine Triphosphate blood
Animals
Fructose-Bisphosphatase metabolism
Glucosephosphate Dehydrogenase metabolism
Kidney enzymology
Liver enzymology
Male
Rats
Rats, Inbred Strains
Cyclic AMP metabolism
Energy Metabolism
Zinc deficiency
Subjects
Details
- Language :
- German
- ISSN :
- 0044-264X
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Zeitschrift fur Ernahrungswissenschaft
- Publication Type :
- Academic Journal
- Accession number :
- 6308919
- Full Text :
- https://doi.org/10.1007/BF02026208