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The effects of beta-(Tyr9)melanotropin-(9-18) and H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH on the analgesic action of morphine.
- Source :
-
Neuropharmacology [Neuropharmacology] 1983 Jan; Vol. 22 (1), pp. 131-4. - Publication Year :
- 1983
-
Abstract
- beta-(Tyr9)melanotropin-(9-18), which itself has no analgesic action, as measured by the tail-flick and hot-plate methods, decreased morphine-induced analgesia following intracerebroventricular injection. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH heptapeptide, which has weak CRF-like activity, had no action on analgesia and was not able to modify morphine-induced analgesia. Compared with ACTH1-24, which in a subcutaneous dose of 100 micrograms/rat decreased morphine-induced analgesia, the same dose of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was ineffective.
Details
- Language :
- English
- ISSN :
- 0028-3908
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuropharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 6302543
- Full Text :
- https://doi.org/10.1016/0028-3908(83)90273-3