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Modulation of passive avoidance behaviour of rats by intracerebroventricular administration of cholecystokinin octapeptide sulfate ester and nonsulfated cholecystokinin octapeptide.
- Source :
-
Acta physiologica Academiae Scientiarum Hungaricae [Acta Physiol Acad Sci Hung] 1981; Vol. 58 (4), pp. 269-74. - Publication Year :
- 1981
-
Abstract
- The effects of intracerebroventricular administration of different doses of cholecystokinin octapeptide sulfate ester (CCK-8-SE) and nonsulfated cholecystokinin octapeptide (CCK-8-NS) were tested on the latency of passive avoidance behaviour in rats. Treatments were carried out prior to learning trial, immediately after electroshock and prior to testing 24 h retention. Both CCK-8-NS and CCK-8-SE enhanced the latency of passive avoidance after all forms of treatment while showing different dose-response patterns depending on time of administration. These data indicate that CCK-8-SE and CCK-8-NS might play a role in the regulation of memory consolidation and retrieval.
Details
- Language :
- English
- ISSN :
- 0001-6756
- Volume :
- 58
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta physiologica Academiae Scientiarum Hungaricae
- Publication Type :
- Academic Journal
- Accession number :
- 6291322