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Release of beta-lipotropin- and beta-endorphin-like material induced by angiotensin in the conscious rat.
- Source :
-
British journal of pharmacology [Br J Pharmacol] 1982 Aug; Vol. 76 (4), pp. 579-85. - Publication Year :
- 1982
-
Abstract
- 1 The influence of the renin-angiotensin system on plasma beta-endorphin-like immunoreactivity (beta-EI) was investigated in the conscious rat by use of a radioimmunoassay for beta-endorphin without prior extraction.2 Intravenous infusion of angiotensin I, II or (des-1-Asp)angiotensin II (angiotensin III) caused a dose-dependent increase in plasma beta-EI, angiotensin III infusion being less effective than angiotensin I or II. The plasma adrenocorticotrophin (ACTH) levels too were elevated by angiotensin II. The receptor antagonist, saralasin, prevented the angiotensin II-induced beta-EI release as did dexamethasone pretreatment.3 Both the release of beta-EI and the pressor response to angiotensin I were abolished by the converting enzyme inhibitor, captopril (SQ 14225). In contrast, captopril did not affect the action of angiotensin II.4 In view of the appreciable cross-reactivity of beta-lipotropin (beta-LPH) in our assay, plasma beta-EI was analysed by Sephadex G-50 chromatography. In plasma extracts of angiotensin II-infused rats, immunoreactivity corresponding to human beta-endorphin comprised about 49% of the total immunoreactivity, whereas 51% co-migrated with human beta-LPH.5 The increase in plasma levels of beta-EI elicited by angiotensin II was diminished by about 35% in rats with a hereditary absolute lack of vasopressin (Brattleboro rats), when compared to normal rats.6 These results suggest that the renin-angiotensin system can stimulate the secretion of beta-LPH and beta-endorphin with ACTH from rat anterior pituitary. One link in mediating the response appears to be vasopressin. The physiological function remains to be defined.
- Subjects :
- Angiotensin I pharmacology
Angiotensin III pharmacology
Animals
Captopril pharmacology
Dexamethasone pharmacology
Drug Interactions
In Vitro Techniques
Male
Rats
Rats, Inbred Strains
Saralasin pharmacology
Species Specificity
beta-Endorphin
Angiotensin II pharmacology
Endorphins metabolism
beta-Lipotropin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1188
- Volume :
- 76
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 6286029
- Full Text :
- https://doi.org/10.1111/j.1476-5381.1982.tb09257.x