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Renin and aldosterone responses to short-term NaCl or NaHCO3 loading in man.
- Source :
-
The Journal of laboratory and clinical medicine [J Lab Clin Med] 1982 Aug; Vol. 100 (2), pp. 261-8. - Publication Year :
- 1982
-
Abstract
- We compared the effects of 500 ml of 0.15M NaCl or 750 ml of 0.15M NaHCO2, infusions on PRA and PAC in 16 normal NaCl-restricted men. More positive sodium balance, greater natriuresis, and lower serum chloride, potassium, and hydrogen ion concentrations were observed after NaHCO3 infusion. PRA decreased (13.8 +/- 1.0 ng/ml angiotensin I per hour to 6.6 +/- 0.70) and PAC did not change (98 +/- 15 ng/dl to 86 +/- 15) after NaCl infusion. Conversely, PRA did not change (9.9 +/- 1.6 to 10.1 +/- 1.6) and PAC decreased (85 +/- 9 to 44 +/- 5) after NaHCO3 infusion. Plasma cortisol declined in both groups. These results suggest that in sodium-restricted man chloride is more important than sodium for the suppression of PRA by NaCl loading and that potassium or hydrogen ion is a more sensitive modulator of aldosterone secretion than is renin.
Details
- Language :
- English
- ISSN :
- 0022-2143
- Volume :
- 100
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of laboratory and clinical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 6284847