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The effects of phenylmethanesulfonyl fluoride on delayed organophosphorus neuropathy.
- Source :
-
Archives of toxicology [Arch Toxicol] 1980 Dec; Vol. 46 (3-4), pp. 305-11. - Publication Year :
- 1980
-
Abstract
- A delayed localized neuropathy of peripheral nerves in a single hind leg of the cat develops after a single intraarterial 2 mg/kg injection of diisopropylfluorophosphate (DFP). This neuropathy is manifested by a maximum loss of the capacity of soleus alpha-motor nerve terminals to generate stimulus-bound repetition 21 days after DFP exposure. Phenylmethanesulfonyl fluoride (PMSF) is a protective inhibitor of the neurotoxic esterase which is associated with the development of the delayed organophosphorus neuropathy. Pretreatment of cats with PMSF (30 mg/kg i.p.) 24 h before the DFP injection protected the cats from the delayed neuropathy. No clinical neurotoxic signs were observed at 21 days after DFP. The stimulus-bound repetitive capacity of soleus alpha-motor nerve terminals was not lost at this time and its incidence was much greater than that which occurred in cats not pretreated with PMSF.
- Subjects :
- Action Potentials drug effects
Animals
Cats
Esterases antagonists & inhibitors
Motor Neurons drug effects
Muscle Contraction drug effects
Peripheral Nervous System Diseases chemically induced
Time Factors
Isoflurophate toxicity
Peripheral Nervous System Diseases prevention & control
Phenylmethylsulfonyl Fluoride pharmacology
Sulfones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0340-5761
- Volume :
- 46
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Archives of toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 6263222
- Full Text :
- https://doi.org/10.1007/BF00310448