Anti leukemia activity (Dunning ascitic) of 6-mercaptopurine and its metallo complexes in rats.

Authors :: Skinner SM
Swatzell JM
Lewis RW
Source :: Research communications in chemical pathology and pharmacology [Res Commun Chem Pathol Pharmacol] 1978 Jan; Vol. 19 (1), pp. 165-8.
Publication Year :: 1978
Abstract: Six-mercaptopurine and its Pt, Pd and Bi complexes were used at various dosage levels to treat Dunning ascitic leukemia in rats. Significant anticarcinogenic activity was found in all compounds with toxicity apparent at the highest dosage level of all but the platinum compound.

Subjects :: Animals
Bismuth adverse effects
Mercaptopurine adverse effects
Palladium adverse effects
Platinum adverse effects
Rats
Rats, Inbred F344
Time Factors
Bismuth therapeutic use
Leukemia, Experimental drug therapy
Mercaptopurine therapeutic use
Palladium therapeutic use
Platinum therapeutic use

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