Back to Search
Start Over
Antiemetics for patients treated with antitumor chemotherapy.
- Source :
-
Cancer clinical trials [Cancer Clin Trials] 1980; Vol. 3 (4), pp. 363-7. - Publication Year :
- 1980
-
Abstract
- The clinical efficacy of antiemetic drugs was tested in cancer patients who were given a placebo and two antiemetic drugs alone and in combination according to random sequences. The method of investigation allowed assessment of the antiemetic effect and side effects of each drug or combination of drugs using a minimum number of patients. The trial design takes into account carry-over effects and biased selection and is potentially useful in the study of drug side effects. Fifteen patients received cyclizine, metoclopramide, cyclizine and metoclopramide, or placebo in a random sequence without evidence that the drugs tested were better than the placebo. A combination of Nabilone and metoclopramide was used in an unrandomized pilot study (prior to the withdrawal of Nabilone from clinical use); these patients recorded better scores for nausea and vomiting and patient acceptability than those in the randomized study. Present antiemetics remain inadequate and although cannabinol derivatives show an improved antiemetic effect, they cause moderate side effects themselves.
- Subjects :
- Adolescent
Adult
Aged
Cyclizine administration & dosage
Dronabinol administration & dosage
Dronabinol analogs & derivatives
Drug Therapy, Combination
Female
Humans
Male
Metoclopramide administration & dosage
Middle Aged
Nausea chemically induced
Nausea drug therapy
Neoplasms drug therapy
Pilot Projects
Vomiting chemically induced
Antiemetics administration & dosage
Cisplatin adverse effects
Vomiting drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0190-1206
- Volume :
- 3
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer clinical trials
- Publication Type :
- Academic Journal
- Accession number :
- 6253100