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Histiocytic malignancies. Morphologic, immunologic, and enzymatic heterogeneity.
- Source :
-
The American journal of surgical pathology [Am J Surg Pathol] 1984 Jul; Vol. 8 (7), pp. 485-500. - Publication Year :
- 1984
-
Abstract
- We have studied 14 hematopoietic malignancies with histologic features of histiocytic differentiation, using frozen section immunologic stains, plastic section enzyme histochemistry, and paraffin section immunocytochemistry. There was morphologic, immunologic, and enzymatic heterogeneity, including findings in seven cases that suggested differentiation toward specialized subsets of histiocytes. Four cases expressed a mature monocyte/macrophage phenotype by frozen section monoclonal antibody staining and three of these had histologic patterns diagnostic of malignant histiocytosis; two other cases had ATPase and S100 protein reactivity and morphologic features consistent with interdigitating (reticulum) cell proliferations; and one case was alkaline phosphatase positive, suggestive of differentiation toward fibroblastic reticulum cells. Four cases had histologic findings consistent with malignant histiocytosis, but weak or unreactive staining patterns and were considered poorly differentiated histiocytic or primitive hematopoietic malignancies. Three other cases, also morphologically consistent with malignant histiocytosis, were identified as probably T-cell lymphomas. The morphologic and phenotypic characteristics of non-neoplastic histiocytes and dendritic cell types and their related neoplasms are discussed. Histiocytic malignancies comprise a diverse group that can be identified and subclassified by immunologic and enzymatic techniques.
- Subjects :
- Adolescent
Adult
Aged
Child
Female
Frozen Sections
Humans
Liver Neoplasms enzymology
Liver Neoplasms immunology
Liver Neoplasms pathology
Lymphatic Diseases enzymology
Lymphatic Diseases immunology
Lymphoma enzymology
Lymphoma immunology
Male
Middle Aged
Skin Neoplasms enzymology
Skin Neoplasms immunology
Skin Neoplasms pathology
Splenic Neoplasms enzymology
Splenic Neoplasms immunology
Splenic Neoplasms pathology
Staining and Labeling
T-Lymphocytes
Lymphatic Diseases pathology
Lymphoma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0147-5185
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The American journal of surgical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 6204546