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Neuropathy and anti-MAG antibodies without detectable serum M-protein.
- Source :
-
Neurology [Neurology] 1984 Feb; Vol. 34 (2), pp. 218-21. - Publication Year :
- 1984
-
Abstract
- Anti-MAG IgM antibodies were detected by ELISA in a patient with slowly progressive peripheral neuropathy. Serum IgM content was normal, and no M-protein was detected by serum protein electrophoresis, immunoelectrophoresis, or immunostaining. By immunoblot analysis, the anti-MAG antibodies were IgMk; they reacted with human and bovine MAG but not with mouse MAG. The data suggest that there was an anti-MAG IgM M-protein in concentration too low to be detected by conventional techniques. Tests for anti-MAG antibodies should be done in patients with slowly progressive neuropathy of unknown etiology, even in the absence of detectable serum M-protein.
Details
- Language :
- English
- ISSN :
- 0028-3878
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 6198602
- Full Text :
- https://doi.org/10.1212/wnl.34.2.218