Back to Search Start Over

Pharmacologic effects in man of a specific serotonin-reuptake inhibitor.

Authors :
Lemberger L
Rowe H
Carmichael R
Oldham S
Horng JS
Bymaster FP
Wong DT
Source :
Science (New York, N.Y.) [Science] 1978 Jan 27; Vol. 199 (4327), pp. 436-7.
Publication Year :
1978

Abstract

Fluoxetine (Li-ly 110140) caused a 63 percent inhibition of [3H]serotonin uptake into platelets obtained from normal volunteers to whom the drug was administered daily for 7 days. This dose had no effect on the usual pressor response produced by injections of norepinephrine or tyramine.

Details

Language :
English
ISSN :
0036-8075
Volume :
199
Issue :
4327
Database :
MEDLINE
Journal :
Science (New York, N.Y.)
Publication Type :
Academic Journal
Accession number :
619465
Full Text :
https://doi.org/10.1126/science.619465