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Alteration of the immunoglobulin G subclass responses in mice to lipopolysaccharide: effects of nonbacterial proteins and bacterial membrane phospholipids or outer membrane proteins of Proteus mirabilis.
- Source :
-
Infection and immunity [Infect Immun] 1983 Apr; Vol. 40 (1), pp. 157-65. - Publication Year :
- 1983
-
Abstract
- The immunoglobulin M (IgM) and the IgG1, IgG2ab, and IgG3 subclasses of plaque-forming cells (PFC) specific for lipopolysaccharide (LPS) were measured after immunization of mice with LPS alone and compared with the responses to LPS in combination with nonbacterial proteins and with bacterial membrane phospholipid vesicles or two major outer membrane proteins from Proteus mirabilis. The relative numbers of IgG PFC belonging to the IgG1, IgG2, or IgG3 subclasses induced by immunization with LPS alone depended upon the type of LPS administered. Phospholipids and the proteins effected characteristic alterations in not only the strength but also the subclass of the IgG responses to LPS. The results suggest that the hydrophobic-hydrophilic nature or state of aggregation of the preparations plays a role in the induction of IgG1 and IgG2 subclasses of PFC specific for LPS. Complex formation with LPS and adjuvant was apparently necessary to obtain these effects.
- Subjects :
- Adjuvants, Immunologic administration & dosage
Animals
Antibody-Producing Cells classification
Antibody-Producing Cells immunology
Bacterial Proteins pharmacology
Cattle
Epitopes
Immunoglobulin G classification
Immunoglobulin M biosynthesis
Mice
Phospholipids pharmacology
Rabbits
Serum Albumin, Bovine pharmacology
Immunoglobulin G biosynthesis
Lipopolysaccharides administration & dosage
Lipopolysaccharides pharmacology
Proteus mirabilis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 40
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 6187689
- Full Text :
- https://doi.org/10.1128/iai.40.1.157-165.1983