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Characterization of human T suppressor-inducer, -precursor and -effector lymphocytes in the antigen-specific plaque-forming cell response.
- Source :
-
European journal of immunology [Eur J Immunol] 1982 Oct; Vol. 12 (10), pp. 860-6. - Publication Year :
- 1982
-
Abstract
- Suppression of an antigen-specific plaque-forming cell response of human blood lymphocytes can be effected by T mu+ cells that have been primed previously by antigen in vitro for 6 days. While lacking the capacity to suppress the plaque-forming response directly, these primed T mu+ suppressor-inducer cells stimulate a subpopulation of unprimed T mu gamma- cells to differentiate to T gamma + suppressor-effector cells. The T mu+, T gamma+ and T mu gamma- subsets have been shown to be heterogeneous populations of cells. Therefore, the functionally defined T suppressor-inducer, -precursor and -effector cells were characterized by OKT monoclonal antibodies and by the capacity to form rosettes with autologous erythrocytes (ar+). Evidence will be presented that in vitro a T4+mu+ar- cell induces a T8+mu gamma-ar+ precursor cell to differentiate to a T8+gamma+ar- suppressor-effector cell. A similar T suppressor-effector cell can also be isolated directly from peripheral blood of normal donors.
- Subjects :
- Antibody-Producing Cells classification
Epitopes
Humans
Ovalbumin immunology
Phenotype
Receptors, Antigen, T-Cell
Rosette Formation
T-Lymphocytes classification
T-Lymphocytes, Regulatory immunology
Antibody-Producing Cells immunology
Hemolytic Plaque Technique
Lymphocyte Activation
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2980
- Volume :
- 12
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 6184239
- Full Text :
- https://doi.org/10.1002/eji.1830121012