Genetic analysis of susceptibility to experimental allergic encephalomyelitis in guinea-pigs.

Genetic analysis of susceptibility to experimental allergic encephalomyelitis (EAE) was performed in guinea-pigs. The results indicate the existence of two Ir genes to EAE in susceptible strain 13 guinea-pigs. One gene is linked to the major histocompatibility complex (MHC) of this species, while the other one is located outside the MHC. The two genes segregate independently and both of them must be expressed to render the animal susceptible to EAE.