[Clinicohematologic effects of hemoglobin Altdorf (alpha 2 beta 2 135 Ala replaced by Pro)].

Authors :: Marti HR
Scherrer R
Piller M
Source :: Folia haematologica (Leipzig, Germany : 1928) [Folia Haematol Int Mag Klin Morphol Blutforsch] 1980; Vol. 107 (4), pp. 648-53.
Publication Year :: 1980
Abstract: Hb Altdorf alpha 2 beta 2 135 Ala leads to Pro is an unstable variant occurring near Lecce in Italy. The abnormal hemoglobin does not separate from Hb A in the electrophoresis. In vitro a marked Heinz body formation is produced with phenylhydrazin. In heterozygous individuals an almost compensated hemolysis and a slight splenomegaly are found. Hemolysis can be aggravated by exogenous factors. A rather severe hemolysis was induced by a viral infection in a 3 years old girl.

Subjects :: Adolescent
Alanine analysis
Child, Preschool
Erythrocytes drug effects
Female
Heinz Bodies
Hemoglobinopathies genetics
Hemoglobins, Abnormal genetics
Hemolysis
Humans
Italy
Male
Middle Aged
Pedigree
Phenylhydrazines pharmacology
Proline analysis
Hemoglobinopathies blood
Hemoglobins, Abnormal analysis

Tools