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Glutamic acid modification of vincristine toxicity.
Glutamic acid modification of vincristine toxicity.
- Source :
-
Cancer biochemistry biophysics [Cancer Biochem Biophys] 1984 Sep; Vol. 7 (3), pp. 245-52. - Publication Year :
- 1984
-
Abstract
- The principal limiting feature of the antitumor agent, vincristine, in the clinic has been neurotoxicity; there are no known agents which can routinely prevent or decrease this side effect. Glutamic acid in laboratory and clinical investigations in the early 1960s was found to antagonize vinblastine, another clinically useful vinca alkaloid. Glutamic acid 250 mg/kg/d i.p. was given to normal mice treated with repetitive doses of vincristine 1.5 mg/kg every other day. When glutamic acid was given both before and during vincristine administration, it produced a 49-79% increase in survival compared to control mice receiving vincristine only (p less than 0.01). Other schedules of glutamic acid administration were ineffective. Also, there appeared to be a delay in development of neurotoxic manifestations (toe-walking gait) but the results were not as consistent as the improvement in survival. Glutamic acid given to tumor-bearing mice (P-388 and P-1534 murine leukemia) did not inhibit the antitumor effect of vincristine-induced host toxicity in a schedule-dependent fashion without inhibition of the antitumor effect of vincristine.
- Subjects :
- Animals
Glutamic Acid
Leukemia P388 drug therapy
Leukemia, Experimental drug therapy
Male
Mice
Mice, Inbred DBA
Nervous System Diseases chemically induced
Nervous System Diseases prevention & control
Vincristine therapeutic use
Glutamates pharmacology
Nervous System drug effects
Vincristine toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0305-7232
- Volume :
- 7
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer biochemistry biophysics
- Publication Type :
- Academic Journal
- Accession number :
- 6149015