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Effect of lodoxamide on the secretory response induced by Escherichia coli and Vibrio cholerae enterotoxins in infant mice.
- Source :
-
Infection and immunity [Infect Immun] 1984 May; Vol. 44 (2), pp. 406-8. - Publication Year :
- 1984
-
Abstract
- The effect of lodoxamide tromethamine, a calcium antagonist, on intestinal fluid accumulation induced by Escherichia coli heat-stable (ST) and Vibrio cholerae (CT) enterotoxins in infant mice was investigated. The simultaneous administration of lodoxamide with ST or CT enterotoxin resulted in a significant (P less than 0.01) inhibition of the intestinal fluid response. A minimum concentration of 10(-7) or 10(-8)M lodoxamide caused an inhibition (P less than 0.01) of the ST- or CT-mediated fluid response, respectively. Treatment of infant mice with buffer or drug alone did not result in fluid accumulation. A significant inhibition of ST and CT enterotoxic activities was also observed when lodoxamide was administered 30 min before (P less than 0.02) or 30 min after (P less than 0.01) toxin challenge. These data suggest that calcium may be important in the ST- or CT-mediated induction of fluid accumulation. Further studies on the potential use of lodoxamide tromethamine in both the prophylaxis and treatment of diarrheal disease appear warranted.
- Subjects :
- Animals
Bacterial Toxins isolation & purification
Biological Assay
Enterotoxins isolation & purification
Escherichia coli Proteins
Gastric Mucosa drug effects
Intestinal Mucosa drug effects
Mice
Nitriles
Oxamic Acid analogs & derivatives
Tromethamine pharmacology
Amino Acids pharmacology
Bacterial Toxins toxicity
Enterotoxins toxicity
Gastric Mucosa metabolism
Histamine H1 Antagonists pharmacology
Intestinal Mucosa metabolism
Oxamic Acid pharmacology
Tromethamine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 44
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 6143729
- Full Text :
- https://doi.org/10.1128/iai.44.2.406-408.1984