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Isolation and identification of 5-acetylamino-6-formylamino-3-methyluracil as a major metabolite of caffeine in man.
- Source :
-
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 1983 May-Jun; Vol. 11 (3), pp. 218-20. - Publication Year :
- 1983
-
Abstract
- An acetylated metabolite produced in man after po administration of caffeine was detected, isolated, and purified using suitable solvent extraction and chromatographic techniques. A set of UV, NMR, and mass spectral data identify it as 5-acetylamino-6-formylamino-3-methyluracil, a structure confirmed by chemical synthesis. This metabolite was shown to be unstable in the presence of dilute base and/or methanol, giving rise to a deformylated compound, 5-acetylamino-6-amino-3-methyluracil, which had recently been reported in the literature as a major metabolite of caffeine in man.
Details
- Language :
- English
- ISSN :
- 0090-9556
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Drug metabolism and disposition: the biological fate of chemicals
- Publication Type :
- Academic Journal
- Accession number :
- 6135579