Anxiety states and benzodiazepines.

Benzodiazepines are effective anxiolytic agents when used properly. They have a high therapeutic-to-toxic ratio and a relatively low rate of physical dependency if the duration of use is limited. They are most effective in ameliorating generalized and post-traumatic anxiety and in relieving the anxiety associated with adjustment reactions. They are less effective for panic attacks and for phobic and obsessive anxiety disorders. The rate of absorption and type of metabolism determine the onset and duration of action.