Back to Search
Start Over
Elimination of carcinoma cells from human bone marrow.
- Source :
-
Lancet (London, England) [Lancet] 1982 Dec 25; Vol. 2 (8313), pp. 1428-30. - Publication Year :
- 1982
-
Abstract
- The value of a monoclonal antibody, LICR-LON-Fib-75 (Fib-75), which mediates complement lysis and recognises an antigen present on all epithelial-tumour cells so far studied but not on lymphoid cells or bone-marrow stem cells, in clearing infiltrated bone marrow was assessed. Chromium-51-release and trypan-blue-exclusion assays showed that no tumour cells were viable after exposure to Fib-75 and complement except when large clumps (greater than 500 cells) were present, whereas Fib-75 had no significant effect on bone-marrow cells, as judged by colony-forming-unit and pluripotential-stem-cell assays.
Details
- Language :
- English
- ISSN :
- 0140-6736
- Volume :
- 2
- Issue :
- 8313
- Database :
- MEDLINE
- Journal :
- Lancet (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 6129508
- Full Text :
- https://doi.org/10.1016/s0140-6736(82)91329-0