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Alloantigenic phenotype of radiation-induced thymomas in the mouse.
- Source :
-
Journal of the National Cancer Institute [J Natl Cancer Inst] 1982 Sep; Vol. 69 (3), pp. 619-26. - Publication Year :
- 1982
-
Abstract
- The alloantigenic phenotype of 21 radiation-induced thymomas is described. Monoclonal antibodies and conventional antisera, absorbed to remove contaminating antibodies, were used to test the thymomas directly for the presence of H-2, Ia, Ly-1, Ly-2, Ly-4, Ly-5, Ly-6, Ly-9, Ly-15, Thy-1, TL, and Qa-2 antigens, and for surface immunoglobulin. The phenotypes obtained by direct tests were also confirmed by absorption studies. The tumors were all of T-cell origin (Thy-1+Ig-) and showed a restricted heterogeneity of their cell surface phenotype, concordant with the known alloantigenic phenotypes of functional T-cells. Thus the thymomas could be classified into 7 groups based on the differing expressions of Ia, Ly-1, Ly-2, Ly-4, and Ly-6 specificities; all tumors were H-2+, Ly-5+, Ly-9+, and Ly-15+. Thus a wide variety of phenotypically diverse tumors could be detected; if these represent the clonal expansion of different functional subsets, they could provide a valuable set of functional T-cells.
- Subjects :
- Animals
Antibodies, Monoclonal
Antigens, Ly analysis
Antigens, Ly genetics
Antigens, Surface analysis
Cell Membrane immunology
H-2 Antigens analysis
Histocompatibility Antigens Class II analysis
Isoantigens genetics
Mice
Mice, Inbred C57BL
Neoplasms, Experimental classification
Neoplasms, Experimental etiology
Neoplasms, Experimental immunology
Phenotype
Thy-1 Antigens
Thymoma classification
Thymoma etiology
Thymus Neoplasms classification
Thymus Neoplasms etiology
Isoantigens analysis
Neoplasms, Radiation-Induced immunology
T-Lymphocytes immunology
Thymoma immunology
Thymus Neoplasms immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8874
- Volume :
- 69
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of the National Cancer Institute
- Publication Type :
- Academic Journal
- Accession number :
- 6125618