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Role of glnA-linked genes in regulation of glutamine synthetase and histidase formation in Klebsiella aerogenes.
- Source :
-
Journal of bacteriology [J Bacteriol] 1982 Apr; Vol. 150 (1), pp. 221-30. - Publication Year :
- 1982
-
Abstract
- We isolated mutants of Klebsiella aerogenes with insertions of transposon Tn5 linked to the structural gene for glutamine synthetase, glnA. We found that K. aerogenes, like Escherichia coli and Salmonella typhimurium, contains a regulatory gene, glnG, which is closely linked to but distinct from glnA. The product of glnG is essential for normal regulation of the synthesis of glutamine synthetase and histidase. We analyzed two mutations which affected the regulation of the formation of these enzymes and appeared to be outside glnG. The results of our studies suggest the presence in K. aerogenes of at least two regulatory genes located in the glnA region, namely, glnG and another gene, the transcription of which can be initiated at the promoter of glnA.
- Subjects :
- Chromosome Mapping
DNA Transposable Elements
Genes
Genetic Linkage
Glutamate-Ammonia Ligase genetics
Klebsiella pneumoniae enzymology
Mutation
Ammonia-Lyases biosynthesis
Genes, Regulator
Glutamate-Ammonia Ligase biosynthesis
Histidine Ammonia-Lyase biosynthesis
Klebsiella pneumoniae genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9193
- Volume :
- 150
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of bacteriology
- Publication Type :
- Academic Journal
- Accession number :
- 6120931
- Full Text :
- https://doi.org/10.1128/jb.150.1.221-230.1982